Sandbox315

This sandbox is in use until June 1, 2009 for UMass Chemistry 490a. Others please do not edit this page. Thanks! Juna Jovani

Macrophage Elastase
Macrophage elastase (MPP-12) is an enzyme mainly expressed in alveolar macrophages in homo sapiens. It gives rise to emphysema by degrading elastin and by deactivating alpha1-proteinase inhibitor (alpha1-PI). The crystal structure of the enzyme was determined by X-ray shows a hydrophobic active-site cleft. The red structures indicate where the hydrophobic residues are located. The enzyme has two beta sheets shown in purple.

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